In this project led by INIBICA, image processing and AI software tools will be developed that allow, using morphometric-based methods, to estimate local changes in the brain volume of premature infants both as a three-dimensional map and by regions of interest (white matter , basal ganglia, thalamus, hippocampus, cerebellum). An iterative computational approach will be carried out to resolve the geometric relationship between anatomical structures, and apply uni- and bivariate statistical procedures to search for differences in brain volume between the study groups, as well as relationships between anatomical and clinical variables.